Adrenal Cortex, Aldosterone, and Hypertension
نویسندگان
چکیده
منابع مشابه
Contribution of the adrenal cortex to renal and renoprival hypertension.
Association of the adrenal cortex with renal hypertension lead to the conclusioa that several mechanisms fare operating. First, hypertension is not, or is poorly sustained in true adrenal failure, and mild failure seems to impair vascular responsiveness. This indicates a permissive function of thme adrenal ill renal hypertension. Furthermore, degrees of renal injury or of hyper(orticoidism whic...
متن کاملEssential hypertension and aldosterone.
MANY FACTORS have been implicated in the etiology of essential hypertension and at present the primary cause of this disease remains obscure. The relationship of sodium to the development of hypertension and the question of involvement of the adrenal cortex has been the subject of numerous investigations. Efforts by earlier investigators to show a hypersecretion of corticosteroids in this condi...
متن کاملUrinary aldosterone and hypertension.
A POSSIBLE ETIOLOGIC ROLE of the 18.1kadrenal cortex in the genesis of clinical hypertension has been recognized since Goldblatt's demonstration in 1937 that adrenalectomy prevents the expected development of hypertension following bilateral renal artery constriction.' Recently, interest in this possibility has been intensified by reports that some hypertensive patients excrete2-6 and secrete7 ...
متن کاملAldosterone Excretion in Virilizing Adrenal
Sodium depletion with concomitant dehydration occurs as a complicating factor in approximately one-third of patients with virilizing adrenal hyperplasia (1). A number of writers have discussed certain differences between the electrolyte disturbance occurring in this syndrome and that of Addison's disease (2-5) and several hypotheses have been offered to explain the sodium loss and potassium ret...
متن کاملMicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex.
Dysregulation of aldosterone or cortisol production can predispose to hypertension, as seen in aldosterone-producing adenoma, a form of primary aldosteronism. We investigated the role of microRNA (miRNA) in their production, with particular emphasis on the CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase) genes, which produce the enzymes responsible for the final stages of cortisol a...
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ژورنال
عنوان ژورنال: Circulation
سال: 1969
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.40.5.739